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Coronary microvascular dysfunction is associated with impaired cognitive function: the cerebral-coronary connection study (C3 study)

Authors: Hernan Mejia-Renteria, Alejandro Travieso, Jordi A Matías-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernández, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gómez-Garré, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-García, Jorge Matías-Guiu, Javier Escaned

Keywords: Ischaemic heart disease, Coronary microvascular dysfunction, Cerebral small vessel disease, Cognitive impairment

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac521/6807333?login=false

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Prognostic association of plasma NT-proBNP levels in patients with microvascular angina – A report from the international cohort study by COVADIS

Akira Suda Jun Takahashi Maike Schwidder Peter Ong Daniel Ang Colin Berry Paolo G. Camici Filippo Crea Juan-Carlos Kaski Carl Pepine Ornella Rimoldi Udo Sechtem Satoshi Yasuda John F. Beltrame C.Noel Bairey Merz Hiroaki Shimokawa on behalf of the Coronary Vasomotor Disorders International Study COVADIS Group

https://www.sciencedirect.com/science/article/pii/S2352906722001889

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Coronary Functional Abnormalities in Patients With Angina and Non obstructive Coronary Artery Disease

Authors: Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu, Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa. 

Lay summary: Various types of coronary microvascular dysfunctions (CMD), such as epicardial coronary artery spasm, reduced coronary flow reserve, and increased coronary microcirculatory resistance, are frequently overlapped even in the same patient with poor long-term prognosis.

https://www.jacc.org/doi/full/10.1016/j.jacc.2019.08.1056

Ref.: J Am CollCardiol. 2019;74(19):2350-2360.

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Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA

Authors: Kensuke Nishimiya, Akira Suda, Kento Fukui, Kiyotaka Hao, Jun Takahashi, Yasuharu Matsumoto, Kiyoto Mitsuishi, Tasuku Watanabe, Kazuma Ohyama, Jun Sugisawa, Satoshi Tsuchiya, Koichi Satoh, Tomohiko Shindo Shigeo Godo, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa. 

Lay summary: OCT studies demonstrate that there are close links between coronary functional dysfunction and  coronary morphological changes.   

https://www.sciencedirect.com/science/article/pii/S1936879820325012?via%3Dihub

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2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L. Bhatt, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, José A. Joglar, David A. Morrow, Robert E. O’Connor, Michael A. Ross and Leslee J. Shaw

Lay Summary – USA Guidelines on how to assess and diagnose chest pain

https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001029?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org

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Safety and prognostic relevance of acetylcholine testing in patients with stable myocardial ischaemia or myocardial infarction and non-obstructive coronary arteries

Rocco Antonio Montone, MD, PhD; Riccardo Rinaldi, MD; Marco Giuseppe Del Buono, MD; Filippo Gurgoglione, MD; Giulia La Vecchia, MD; Michele Russo, MD, PhD; Andrea Caffè, MD; Francesco Burzotta, MD, PhD; Antonio Maria Leone, MD; Enrico Romagnoli, MD; Tommaso Sanna, MD; Gemma Pelargonio, MD; Carlo Trani, MD; Gaetano Antonio Lanza, MD; Giampaolo Niccoli, MD, PhD; Filippo Crea, MD, PhD

Lay Summary – Discussing the safety of Acetylcholine testing in pateints with INOCA

https://eurointervention.pcronline.com/article/safety-and-prognostic-relevance-of-acetylcholine-testing-in-patients-with-stable-myocardial-ischaemia-or-myocardial-infarction-and-non-obstructive-coronary-arteries

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Can you describe the relationship between CAS, CMVD and Endothelial Dysfunction?

Myocardial ischaemia has been traditionally perceived as the consequence of atherosclerotic obstructions of the coronary vessels. More recently an overwhelming body of evidence has proven that atherosclerotic obstructions are just one of several mechanisms that can precipitate myocardial ischaemia. CAS, CMVD and Endothelial Dysfunction are included among the mechanisms that, in isolated fashion or in combination, may cause myocardial ischaemia