{"id":5459,"date":"2022-08-15T15:07:14","date_gmt":"2022-08-15T14:07:14","guid":{"rendered":"https:\/\/inocainternational.com\/?page_id=5459"},"modified":"2024-10-21T10:18:49","modified_gmt":"2024-10-21T09:18:49","slug":"ask-our-experts","status":"publish","type":"page","link":"https:\/\/inocainternational.com\/es\/ask-our-experts\/","title":{"rendered":"Pregunta A Nuestros Expertos"},"content":{"rendered":"<div class=\"wp-block-group redesign-featured-group is-vertical is-layout-flex wp-container-core-group-is-layout-8cf370e7 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-large featured-image-redesign\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" width=\"525\" height=\"351\" src=\"https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image.jpg?resize=525%2C351&#038;ssl=1\" alt=\"\" class=\"wp-image-5261\" srcset=\"https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=1024%2C685&amp;ssl=1 1024w, https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=300%2C201&amp;ssl=1 300w, https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=768%2C514&amp;ssl=1 768w, https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=1536%2C1028&amp;ssl=1 1536w, https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=2048%2C1371&amp;ssl=1 2048w, https:\/\/i0.wp.com\/inocainternational.com\/wp-content\/uploads\/2022\/08\/info-image-scaled.jpg?resize=500%2C335&amp;ssl=1 500w\" sizes=\"(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\">Pregunta A Nuestros Expertos<\/h2>\n\n\n\n<div class=\"wp-block-columns redesign-feature-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column redesign-feature-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><br><br><em>&#8220;<\/em>La angiograf\u00eda de rutina s\u00f3lo eval\u00faa el\nestado de reposo de las arterias coronarias\nepic\u00e1rdicas\u201d<br><br>  <em><mark style=\"background-color:rgba(0, 0, 0, 0);color:#d7e1ea\" class=\"has-inline-color\">Kaski, Berry y Ang <\/mark><\/em><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column redesign-feature-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">Aqu\u00ed encontrar\u00e1s informaci\u00f3n de nuestros\nestimados miembros del Consejo Asesor\nM\u00e9dico y de expertos en sus campos.\nPuedes utilizar los filtros a continuaci\u00f3n para\nseleccionar \u00e1reas de inter\u00e9s particulares.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-center\">If you would like to submit a question please send your question via the contact us link at the bottom of the page and we will do our best to get an answer for you<br><br>Please also remember to join us on our social media platforms to keep up to date with all the latest information and updates too!<br>Twitter:\u00a0<mark><mark style=\"background-color:rgba(0, 0, 0, 0);color:#7d1f5f\" class=\"has-inline-color\">@InocaInternati1<\/mark><\/mark><br>Facebook:\u00a0<a href=\"https:\/\/www.facebook.com\/groups\/491395198372627\">https:\/\/www.facebook.com\/groups\/491395198372627<\/a><br>Instagram:\u00a0<a href=\"https:\/\/www.instagram.com\/inoca_international\/\">https:\/\/www.instagram.com\/inoca_international\/<\/a><br>TikTok:\u00a0<a href=\"https:\/\/www.tiktok.com\/@inoca_international\">https:\/\/www.tiktok.com\/@inoca_international<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-text-color has-background\" style=\"background-color:#5b9bd5;font-size:30px\"><strong>Patient Questions<\/strong><\/h2>\n\n\n<!-- The Grid Plugin Version 2.7.9.5 --><!-- The Grid Wrapper Start --><div class=\"tg-grid-wrapper articles-grid tg-grid-loading tg-nav-under\" id=\"grid-5461\" data-version=\"2.7.9.5\"><!-- The Grid Styles --><style class=\"tg-grid-styles\" type=\"text\/css\">#grid-5461{margin-top:12px;margin-bottom:12px;margin-left:40px;margin-right:40px}#grid-5461 .tg-nav-color:not(.dots):not(.tg-dropdown-value):not(.tg-dropdown-title):not(.tg-filter-name):hover,#grid-5461 .tg-page-number.tg-page-current,#grid-5461 .tg-filter-active span:not(.tg-filter-count){color:#872467}#grid-5461 .tg-filter:not(.tg-dropdown-item):after{border-bottom:3px solid #872467}#grid-5461 .tg-search-holder:before,#grid-5461 .tg-dropdown-holder:before,#grid-5461 .tg-filter:not(.tg-dropdown-item):before{border-bottom:1px solid #D7B6CC}.tg-nav-under 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sorters holder --><div class=\"tg-sorters-holder\"><div class=\"tg-dropdown-holder tg-nav-border tg-nav-font\"><span class=\"tg-dropdown-title tg-nav-color tg-nav-font\">Sort By<\/span>&nbsp;<span class=\"tg-dropdown-value tg-nav-color tg-nav-font\">Popular post<\/span><ul class=\"tg-dropdown-list tg-sorter grid-5461\"><li class=\"tg-dropdown-item\"  data-value=\"none\">None<\/li><li class=\"tg-dropdown-item\"  data-value=\"date\">Date<\/li><li class=\"tg-dropdown-item\"  data-value=\"title\">Title<\/li><li class=\"tg-dropdown-item\"  data-value=\"popular_post\">Popular post<\/li><\/ul><\/div><div class=\"tg-sorter-order tg-nav-color tg-nav-border\" data-asc=\"false\"><i class=\"tg-icon-sorter-down tg-nav-color tg-nav-font\"><\/i><i class=\"tg-icon-sorter-up tg-nav-color tg-nav-font\"><\/i><\/div><\/div><!-- The Grid Search holder --><div class=\"tg-search-holder\"><div class=\"tg-search-inner tg-nav-border\"><span class=\"tg-search-icon tg-nav-color tg-nav-font\"><\/span><input type=\"text\" class=\"tg-search tg-nav-color tg-nav-font\" autocomplete=\"off\" placeholder=\"Search Articles...\" \/><span class=\"tg-search-clear tg-nav-color tg-nav-border tg-nav-font\"><\/span><\/div><\/div><\/div><!-- The Grid Items Holder --><div class=\"tg-grid-holder tg-layout-masonry\"  data-name=\"Ask Our Experts\"  data-style=\"masonry\" data-row=\"1\" data-layout=\"vertical\" data-rtl=\"\" data-fitrows=\"\" data-filtercomb=\"\" data-filterlogic=\"AND\" data-filterload =\"\" data-sortbyload =\"popular_post\" data-orderload =\"false\" data-fullwidth=\"\" data-fullheight=\"null\" data-gutters=\"[[320,8],[480,8],[690,8],[1000,8],[1300,8],[9999,8]]\" data-slider='{\"itemNav\":\"null\",\"swingSpeed\":0.1,\"cycleBy\":\"null\",\"cycle\":5000,\"startAt\":1}' data-ratio=\"1.00\" data-cols=\"[[320,1],[480,1],[690,1],[1000,2],[1300,2],[9999,4]]\" data-rows=\"[[320,200],[480,200],[690,220],[1000,220],[1300,240],[9999,240]]\" data-animation='{&quot;name&quot;:&quot;Fade in&quot;,&quot;visible&quot;:&quot;&quot;,&quot;hidden&quot;:&quot;&quot;}' data-transition=\"700ms\" data-ajaxmethod=\"\" data-ajaxdelay=\"100\" data-preloader=\"1\" data-itemdelay=\"100\" data-gallery=\"\" data-ajax=\"\"><!-- The Grid item #1 --><article class=\"tg-item tg-post-5372 tg-questions-masonry f654 f736 f737 tg-item-reveal\" data-date=\"1659819817\" data-title=\"Can areas of\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-areas-of-inducible-ischaemia-seen-on-mri-improve-or-do-they-get-worse-over-time\/\">Can areas of inducible Ischaemia (seen on MRI) improve or do they get worse over time?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Transient myocardial ischemia is reversible with no residual damage, unless severe and prolonged enough to cause cell death. Inducible ischemia may get worse if the responsible mechanism changes.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5372\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #2 --><article class=\"tg-item tg-post-5370 tg-questions-masonry f654 f114 f254 f734 f735 tg-item-reveal\" data-date=\"1659819729\" data-title=\"What is Sube\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-is-subendocardial-perfusion-defect-is-that-microvascular-dysfunction\/\">What is Subendocardial perfusion defect \u2013 is that Microvascular dysfunction?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">The subendocardial layers of the left ventricular wall are more sensitive to ischemia. Infarcts\u00a0 start\u00a0 in the subendocardium and progressively extend\u00a0 to the mid and subepicardial layers if ischemia is severe and prolonged enough. It is not exclusive of microvascular dysfunction, but of any mechanism that\u00a0 may precipitate myocardial infarction .<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5370\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #3 --><article class=\"tg-item tg-post-5368 tg-questions-masonry f654 f729 f727 f728 f732 f733 f731 f730 tg-item-reveal\" data-date=\"1659819616\" data-title=\"Can you expl\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-you-explain-a-little-about-how-calcium-channel-blockers-and-ranolazine-work-in-the-body-and-why-they-work-please\/\">Can you explain a little about how Calcium channel blockers and Ranolazine work in the body and why they work please?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Calcium transients are an essential mechanism in muscle cell contractile function. Calcium channel blockers reduce the tone of vascular smooth muscle cells, resulting in vasodilation and reduced resistance to flow and in the prevention of hypercontraction in response to stimuli. Ranolazine is a metabolic modulator that favours cell utilisation of glucose instead of free fatty &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-you-explain-a-little-about-how-calcium-channel-blockers-and-ranolazine-work-in-the-body-and-why-they-work-please\/\" class=\"more-link\">Continue reading \"Can you explain a little about how Calcium channel blockers and Ranolazine work in the body and why they work please?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5368\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #4 --><article class=\"tg-item tg-post-5366 tg-questions-masonry f654 f726 f723 f724 tg-item-reveal\" data-date=\"1659817250\" data-title=\"What is the \" data-popular-post=\"1\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-is-the-cause-mechanism-of-the-delayed-angina-reported-where-patients-perform-an-activity-but-angina-is-felt-hours-later\/\">What is the cause\/mechanism of the delayed angina reported, where patients perform an activity but angina is felt hours later?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Angina reported hours after activity simply is not triggered by that activity but by other mechanisms. The heart does not \u201cremember\u201d what has he been doing hours before.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5366\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">1<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #5 --><article class=\"tg-item tg-post-5364 tg-questions-masonry f654 f721 f114 f715 f722 tg-item-reveal\" data-date=\"1659817114\" data-title=\"How is it th\" data-popular-post=\"1\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/how-is-it-that-the-oximeter-can-show-acceptable-levels-of-oxygen-when-we-are-struggling-with-ischaemia-does-microvascular-ischaemia-not-show-on-an-oximeter\/\">How is it that the oximeter can show acceptable levels of oxygen when we are struggling with Ischaemia? Does microvascular ischaemia not show on an Oximeter?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Ischemia is a\u00a0 condition of the cardiac muscle precipitated by local mechanisms. It is not directly related to hypoxia in the systemic circulation,\u00a0 with the possible exception of rare and dramatic conditions of systemic severe hypoxia.\u00a0<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5364\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">1<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #6 --><article class=\"tg-item tg-post-5362 tg-questions-masonry f654 f716 f720 f719 f715 f717 f718 tg-item-reveal\" data-date=\"1659817001\" data-title=\"What is the \" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-is-the-difference-between-reading-oxygen-levels-on-an-oximeter-and-via-an-abg-blood-test-which-is-the-best-test-or-the-best-indication-for-inoca-patients\/\">What is the difference between reading oxygen levels on an Oximeter and via an ABG blood test? Which is the best test or the best indication for INOCA patients?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">The Oximeter reads the Oxygen saturation of circulating haemoglobin, that is the percentage of Hb bound to oxygen. ABG blood test provides much more detailed information on circulation arterial blood gases, including oxygen and Carbon dioxide concentrations, pH, Hb etc etc<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5362\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #7 --><article class=\"tg-item tg-post-5360 tg-questions-masonry f654 f712 f711 f714 f713 tg-item-reveal\" data-date=\"1659816890\" data-title=\"Is Cadasil a\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/is-cadasil-a-known-cause-for-inoca\/\">Is Cadasil a known cause for INOCA?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">CADASIL (Cerebral Autosomal Dominat Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a dominant autonomic disease associated with migraine, cognitive impairment, cerebral infarcts and eventually dementia. I am not aware of an association with INOCA<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5360\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #8 --><article class=\"tg-item tg-post-5358 tg-questions-masonry f654 f206 f116 f708 f710 f709 tg-item-reveal\" data-date=\"1659816801\" data-title=\"8.2% increas\" data-popular-post=\"2\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/8-2-increased-mace-over-5-4-years-was-recently-reported-by-the-wise-study-what-does-could-this-mean-for-the-significance-of-inoca-diagnosis-treatment-for-the-future\/\">8.2% increased MACE over 5.4 years was recently reported by the WISE study \u2013 what does\/could this mean for the significance of INOCA diagnosis\/treatment for the future?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">This observation further supports the notion that outcome of ischemic patients is dictated by extension and severity of myocardial ischemia more than by the mechanisms responsible for ischemia.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5358\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">2<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #9 --><article class=\"tg-item tg-post-5356 tg-questions-masonry f654 f705 f706 f704 f707 tg-item-reveal\" data-date=\"1659816694\" data-title=\"Is CMVD syst\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/is-cmvd-systemic-or-is-it-just-in-the-coronary-vessels\/\">Is CMVD systemic or is it just in the coronary vessels?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">This is a very important question with limited scientific evidence to support any answer. However, the physiology of the coronary circulation is so peculiar that systemic microvascular dysfunction (if it does exist) would have unique consequences in the coronary circulation.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5356\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #10 --><article class=\"tg-item tg-post-5354 tg-questions-masonry f654 f703 f700 f702 f701 tg-item-reveal\" data-date=\"1659816590\" data-title=\"Can Coronary\" data-popular-post=\"2\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-coronary-microvascular-dysfunction-get-better-or-will-it-just-get-worse\/\">Can Coronary Microvascular Dysfunction get better or will it just get worse?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Coronary Microvascular Dysfunction is a dynamic condition that can be stable or get better or worse in time, either spontaneously or in association with treatment. It has been reported that MD can resolve after a few months after an acute coronary syndrome.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5354\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">2<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #11 --><article class=\"tg-item tg-post-5352 tg-questions-masonry f654 f697 f699 f698 tg-item-reveal\" data-date=\"1659807111\" data-title=\"Have you see\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/have-you-seen-an-increase-in-patients-presenting-with-cas-cmvd-as-a-result-of-increased-awareness\/\">Have you seen an increase in patients presenting with CAS\/CMVD as a result of increased awareness?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">I\u2019m not sure that I have seen an increase in patients presenting with CAS\/CMVD but we are in rather unusual times! Certainly before lockdown I had queried the diagnosis in several of my patients and sent them off to cardiology for investigation. I think it is more my increased awareness that has changed rather than &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/have-you-seen-an-increase-in-patients-presenting-with-cas-cmvd-as-a-result-of-increased-awareness\/\" class=\"more-link\">Continue reading \"Have you seen an increase in patients presenting with CAS\/CMVD as a result of increased awareness?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5352\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #12 --><article class=\"tg-item tg-post-5350 tg-questions-masonry f654 f696 f693 f695 f694 f671 tg-item-reveal\" data-date=\"1659807016\" data-title=\"Is it ok to \" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/is-it-ok-to-have-vitamin-d-levels-just-above-the-lower-limit-of-normal\/\">Is it ok to have Vitamin D levels just above the lower limit of normal?\u00a0<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">It depends! If you are just above the lower limit of normal and it is the start of the winter then I would be looking to optimise your level by taking a supplement as it is likely to drop further without strong sunlight exposure. If it is at the start of the summer months or &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/is-it-ok-to-have-vitamin-d-levels-just-above-the-lower-limit-of-normal\/\" class=\"more-link\">Continue reading \"Is it ok to have Vitamin D levels just above the lower limit of normal?\u00a0\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5350\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #13 --><article class=\"tg-item tg-post-5348 tg-questions-masonry f654 f682 f690 f680 f683 f691 f689 f692 f684 f686 f688 f685 f687 f681 tg-item-reveal\" data-date=\"1659806917\" data-title=\"What are the\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-are-the-main-symptoms-of-b12-vitamin-deficiency\/\">What are the main symptoms of B12 Vitamin deficiency?\u00a0<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Vitamin B12 deficiency can affect every body system potentially. It is more common in vegetarians and vegans as it is mostly available from animal sources but also common in people taking certain medications which reduce its absorption from the stomach and anyone with malabsorption disorders such as coeliac disease or after gastric bypass surgery.\u00a0 I &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-are-the-main-symptoms-of-b12-vitamin-deficiency\/\" class=\"more-link\">Continue reading \"What are the main symptoms of B12 Vitamin deficiency?\u00a0\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5348\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #14 --><article class=\"tg-item tg-post-5346 tg-questions-masonry f654 f676 f673 f677 f672 f675 f162 f674 f679 f671 tg-item-reveal\" data-date=\"1659806784\" data-title=\"What are the\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-are-the-main-symptoms-of-vitamin-d-deficiency\/\">What are the main symptoms of Vitamin D deficiency?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">The common symptoms I find in general practice are musculoskeletal pains. But vitamin D is involved in so many other body processes, not just bone and muscle health. It has roles in the immune system, in blood sugar regulation, cancer prevention, it helps to reduce inflammation and is important in mental illness too. It is &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-are-the-main-symptoms-of-vitamin-d-deficiency\/\" class=\"more-link\">Continue reading \"What are the main symptoms of Vitamin D deficiency?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5346\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #15 --><article class=\"tg-item tg-post-5344 tg-questions-masonry f654 f670 f203 f143 f668 f669 tg-item-reveal\" data-date=\"1659806652\" data-title=\"Can we worse\" data-popular-post=\"2\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-we-worsen-our-condition-in-cas-or-cmvd-if-we-push-through-the-pain-of-angina\/\">Can we worsen our condition (in CAS or CMVD) if we push through the pain of angina?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Angina associated with severe coronary stenosis is triggered by exercise and relieved by rest. Angina associated with CAS or CMVD is not precipitated by excess cardiac work but by transient impairment of myocardial perfusion. But the common background is always cellular ischaemia and therefore it is difficult to imagine that pushing through might be irrelevant.<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5344\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">2<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #16 --><article class=\"tg-item tg-post-5342 tg-questions-masonry f654 f55 f42 f667 f666 tg-item-reveal\" data-date=\"1659806532\" data-title=\"Why does ang\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/why-does-angina-cause-fatigue\/\">Why does angina cause fatigue?\u00a0<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Angina by definition is a transient Ischaemic \u00a0episodes not leading to \u00a0cellular death. As \u00a0such it should not cause chronic fatigue. However, during an anginal episode, if the ischaemic territory is large enough or if critical component of the heart are involved (e.g. Papillary muscles and mitral valve), then it may be associated with fatigue &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/why-does-angina-cause-fatigue\/\" class=\"more-link\">Continue reading \"Why does angina cause fatigue?\u00a0\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5342\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #17 --><article class=\"tg-item tg-post-5340 tg-questions-masonry f654 f664 f203 f144 f143 f665 f663 tg-item-reveal\" data-date=\"1659806391\" data-title=\"Could it dam\" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/could-it-damage-the-heart-over-time-to-have-repeat-cmvd-cas-events\/\">Could it damage the heart over time to have repeat CMVD \/ CAS events?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Both CMVD and CAS may caused prolonged myocardial ischaemia leading to myocardial infarction. So, both mechanisms may be associated with permanent cardiac damage through multiple episodes or prolonged episodes<\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5340\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #18 --><article class=\"tg-item tg-post-5338 tg-questions-masonry f654 f203 f144 f143 f110 f116 f242 tg-item-reveal\" data-date=\"1659805663\" data-title=\"Can you desc\" data-popular-post=\"1\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-you-describe-the-relationship-between-cas-cmvd-and-endothelial-dysfunction\/\">Can you describe the relationship between CAS, CMVD and Endothelial Dysfunction?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">Myocardial ischaemia has been traditionally perceived as the consequence of atherosclerotic obstructions of the coronary vessels. More recently an overwhelming body of evidence has proven that atherosclerotic obstructions are just one of several mechanisms that can precipitate myocardial ischaemia. CAS, CMVD and Endothelial Dysfunction are included among the mechanisms that, in isolated fashion or in &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/can-you-describe-the-relationship-between-cas-cmvd-and-endothelial-dysfunction\/\" class=\"more-link\">Continue reading \"Can you describe the relationship between CAS, CMVD and Endothelial Dysfunction?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5338\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">1<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #19 --><article class=\"tg-item tg-post-5336 tg-questions-masonry f654 f55 f221 f144 f120 f658 f141 f661 f659 f108 f657 f655 tg-item-reveal\" data-date=\"1659805533\" data-title=\"What is the \" data-popular-post=\"1\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-is-the-difference-between-endothelium-dependent-cmd-and-non-endothelium-dependent-cmd-2\/\">What is the difference between Endothelium Dependent CMD and non Endothelium Dependent CMD?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">The wall of the blood vessel (coronary artery) supplying the heart muscle has got three layers: the innermost layer contains&nbsp;endothelial cells, the middle layer contains the&nbsp;smooth muscle cells&nbsp;and the outermost layer contains collagen fibres for support. The endothelial cells naturally release a substance called&nbsp;nitric oxide (NO), that then diffuses along into the neighbouring smooth muscle &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/06\/what-is-the-difference-between-endothelium-dependent-cmd-and-non-endothelium-dependent-cmd-2\/\" class=\"more-link\">Continue reading \"What is the difference between Endothelium Dependent CMD and non Endothelium Dependent CMD?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked\" data-post-id=\"5336\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">1<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><!-- The Grid item #20 --><article class=\"tg-item tg-post-5330 tg-questions-masonry f654 tg-item-reveal\" data-date=\"1659703812\" data-title=\"What is the \" data-popular-post=\"0\" data-row=\"1\" data-col=\"1\"><div class=\"tg-item-inner\"><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"top\"><h2 class=\"tg-item-title tg-element-3\"><a target=\"_self\" href=\"https:\/\/inocainternational.com\/es\/2022\/08\/05\/what-is-the-difference-between-endothelium-dependent-cmd-and-non-endothelium-dependent-cmd\/\">What is the difference between Endothelium Dependent CMD and non Endothelium Dependent CMD?<\/a><\/h2><div class=\"tg-item-clear\"><\/div><\/div><div class=\"tg-item-content-holder tg-dark standard-format\" data-position=\"bottom\"><p class=\"tg-item-excerpt tg-element-5\">The wall of the blood vessel (coronary artery) supplying the heart muscle has got three layers: the innermost layer contains&nbsp;endothelial cells, the middle layer contains the&nbsp;smooth muscle cells&nbsp;and the outermost layer contains collagen fibres for support. The endothelial cells naturally release a substance called&nbsp;nitric oxide (NO), that then diffuses along into the neighbouring smooth muscle &hellip; <a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/05\/what-is-the-difference-between-endothelium-dependent-cmd-and-non-endothelium-dependent-cmd\/\" class=\"more-link\">Continue reading \"What is the difference between Endothelium Dependent CMD and non Endothelium Dependent CMD?\"<\/a><\/p><span class=\"no-ajaxy to-post-like tg-element-8 no-liked empty-heart\" data-post-id=\"5330\" title=\"Like\"><span class=\"to-heart-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" viewbox=\"0 0 64 64\"><g transform=\"translate(0, 0)\"><path stroke-width=\"6\" stroke-linecap=\"square\" stroke-miterlimit=\"10\" d=\"M1,21c0,20,31,38,31,38s31-18,31-38 c0-8.285-6-16-15-16c-8.285,0-16,5.715-16,14c0-8.285-7.715-14-16-14C7,5,1,12.715,1,21z\"><\/path><\/g><\/svg><\/span><span class=\"to-like-count\">0<\/span><\/span><div class=\"tg-item-clear\"><\/div><\/div><\/div><\/article><\/div><div class=\"tg-grid-preloader\"><style class=\"tg-grid-preloader-styles\" type=\"text\/css\">@-webkit-keyframes square-spin{25%{-webkit-transform:perspective(100px) rotateX(180deg) rotateY(0);transform:perspective(100px) rotateX(180deg) rotateY(0)}50%{-webkit-transform:perspective(100px) rotateX(180deg) rotateY(180deg);transform:perspective(100px) rotateX(180deg) rotateY(180deg)}75%{-webkit-transform:perspective(100px) rotateX(0) rotateY(180deg);transform:perspective(100px) rotateX(0) rotateY(180deg)}100%{-webkit-transform:perspective(100px) rotateX(0) rotateY(0);transform:perspective(100px) rotateX(0) rotateY(0)}}@keyframes square-spin{25%{-webkit-transform:perspective(100px) rotateX(180deg) rotateY(0);transform:perspective(100px) rotateX(180deg) rotateY(0)}50%{-webkit-transform:perspective(100px) rotateX(180deg) rotateY(180deg);transform:perspective(100px) rotateX(180deg) rotateY(180deg)}75%{-webkit-transform:perspective(100px) rotateX(0) rotateY(180deg);transform:perspective(100px) rotateX(0) rotateY(180deg)}100%{-webkit-transform:perspective(100px) rotateX(0) rotateY(0);transform:perspective(100px) rotateX(0) rotateY(0)}}.square-spin>div{width:50px;height:50px;-webkit-animation:square-spin 3s 0s cubic-bezier(.09,.57,.49,.9) infinite;animation:square-spin 3s 0s cubic-bezier(.09,.57,.49,.9) infinite}#grid-5461 .tg-grid-preloader-inner>div{background:#872467}#grid-5461 .tg-grid-preloader-scale{transform:scale(1)}<\/style><div class=\"tg-grid-preloader-holder\"><div class=\"tg-grid-preloader-scale\"><div class=\"tg-grid-preloader-inner square-spin\"><div><\/div><\/div><\/div><\/div><\/div><\/div><!-- The Grid Wrapper End -->","protected":false},"excerpt":{"rendered":"<p>Ask Our Experts &#8220;Routine angiography only evaluates the resting state of the epicardial coronary arteries&#8221; Kaski, Berry and Ang On this page you will find frequently asked questions about INOCA with general responses from members of our Medical Advisory Board and doctors treating INOCA. Please note that answers given are not specific to individual circumstances. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/inocainternational.com\/es\/2022\/08\/05\/what-is-the-difference-between-endothelium-dependent-cmd-and-non-endothelium-dependent-cmd\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;What is the difference between Endothelium Dependent CMD and non Endothelium Dependent CMD?&#8221;<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5459","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/pages\/5459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/comments?post=5459"}],"version-history":[{"count":5,"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/pages\/5459\/revisions"}],"predecessor-version":[{"id":10056,"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/pages\/5459\/revisions\/10056"}],"wp:attachment":[{"href":"https:\/\/inocainternational.com\/es\/wp-json\/wp\/v2\/media?parent=5459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}