Articles

JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction

Authors: Seiji Hokimoto, Koichi Kaikita, Satoshi Yasuda, Kenichi Tsujita, Masaharu Ishihara, Tetsuya Matoba, Yasushi Matsuzawa, Yoshiaki Mitsutake, Yoshihide Mitani, Toyoaki Murohara, Takashi Noda, Koichi Node, Teruo Noguchi, Hiroshi Suzuki, Jun Takahashi, Yasuhiko Tanabe, Atsushi Tanaka, Nobuhiro Tanaka, Hiroki Teragawa, Takanori Yasu, Michihiro Yoshimura, Yasuhide Asaumi, Shigeo Godo, Hiroki Ikenaga, Takahiro Imanaka, Kohei Ishibashi, Masanobu Ishii, … Continue reading "JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction"

Endotypes of coronary microvascular dysfunction in patients with and without Diabetes Mellitus

Authors: E Gallinoro, P Paolisso, D T Bertolone, M Belmonte, G Esposito, D Munhoz, K Sakai, K Bermpeis, H Ohashi, T Storozhenko, R Seki, J Sonck, C Collet, B De Bruyne, E Barbato Endotypes of coronary microvascular dysfunction in patients with and without Diabetes Mellitus

Coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries: Where do we stand?

Authors: Abdul-Quddus Mohammed, Fuad A. Abdu, Lu Liu, Guoqing Yin, Redhwan M. Mareai, Ayman A. Mohammed, Yawei Xu, Wenliang Che Coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries: Where do we stand? – ScienceDirect

Pathophysiology of coronary microvascular dysfunction

Authors: Filippo Crea , Rocco A Montone Pathophysiology of coronary microvascular dysfunction – PubMed

Coronary “Microvascular Dysfunction”: Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics

Authors: Chun Yeung Kei , Kuljit Singh , Rustem F Dautov , Thanh H Nguyen , Yuliy Y Chirkov, John D Horowitz Coronary “Microvascular Dysfunction”: Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics

Microvascular arterial disease of the brain and the heart: a shared pathogenesis 

Authors: C P Bradley, C Berry Microvascular arterial disease of the brain and the heart: a shared pathogenesis

Coronary microvascular dysfunction is a hallmark of all subtypes of MINOCA

Authors: Andrea Milzi , Rosalia Dettori , Richard Karl Lubberich , Sebastian Reith , Michael Frick , Kathrin Burgmaier , Nikolaus Marx , Mathias Burgmaier Coronary microvascular dysfunction is a hallmark of all subtypes of MINOCA – Clinical Research in Cardiology

Coronary Microvascular Dysfunction

Authors: Yader Sandoval MD, Joaquin E. Cigarroa MD, George D. Dangas MD, PhD, Alexandra J. Lansky MD, Srihari S. Naidu MD, Sunil V. Rao MD, Arnold H. Seto MD, MPA, Samit Shah MD, PhD, Adhir R. Shroff MD, MPH, Olga Toleva MD, Jennifer A. Tremmel MD, Robert F. Riley MD, Timothy D. Henry MD, SCAI … Continue reading "Coronary Microvascular Dysfunction"

Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International

Authors: Sachini Ranasinghe, C. Noel Bairy Merz, Najah Khan, Janet Wei, Maria George, Colin Berry, Alaide Chieffo, Pablo G. Camici, Filippo Crea, Juan Carlos Kaski, Mario Marzilli and Martha Gulati Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International

Comprehensive Management of ANOCA, Part 1-Definition, Patient Population, and Diagnosis: JACC State-of-the-Art Review

Authors: Bruce A Samuels, Samit M Shah, R Jay Widmer, Yuhei Kobayashi, Steven E S Miner, Viviany R Taqueti, Allen Jeremias, Ahmed Albadri, John A Blair, Kathleen E Kearney, Janet Wei, Ki Park, Ailin Barseghian El-Farra, Noa Holoshitz, Katherine B Janaszek, Manoj Kesarwani, Amir Lerman, Megha Prasad, Odayme Quesada, Harmony R Reynolds, Michael P Savage, … Continue reading "Comprehensive Management of ANOCA, Part 1-Definition, Patient Population, and Diagnosis: JACC State-of-the-Art Review"

Invasive Coronary Assessment in Myocardial Ischemia with No Obstructive Coronary Arteries

Authors: Tatsunori Takahashi, Aakriti Gupta, Bruce A. Samuels, and Janet Wei Invasive Coronary Assessment in Myocardial Ischemia with No Obstructive Coronary Arteries – Current Atherosclerosis Reports

Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA)

Authors: Yasmeen K. Taha, Jennifer R. Duggan, Michael T. Weaver, Ke Xu, Eileen M. Handberg, Carl J. Pepine, C. Noel Bairy Merz Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA)

Evaluation of Ischemia with No Obstructive Coronary Arteries (INOCA) and Contemporary Applications of Cardiac Magnetic Resonance (CMR)

Authors: Andrew Chang, Nicolas Kang, Joseph Chung, Aakash Rai Gupta, and Purvi Parwani Evaluation of Ischemia with No Obstructive Coronary Arteries (INOCA) and Contemporary Applications of Cardiac Magnetic Resonance (CMR) – PMC

Exploring coronary microvascular function by quantitative CZT-SPECT: a small step or giant leap for INOCA patients?

Authors: N Odanovic, A Schwann, Z Zhang, S Kapadia, S Kunnirickal, H Parise, D Tirziu, I Ilic, A Lansky, C Pietras, S Shah Exploring coronary microvascular function by quantitative CZT-SPECT: a small step or giant leap for INOCA patients? – European Journal of Nuclear Medicine and Molecular Imaging

Long-term outcomes of patients with ischemia and no obstructive coronary artery disease (INOCA) – a systematic review and meta-analysis

Authors: N Odanovic, A Schwann, Z Zhang, S Kapadia, S Kunnirickal, H Parise, D Tirziu, I Ilic, A Lansky, C Pietras, S Shah Long-term outcomes of patients with ischemia and no obstructive coronary artery disease (INOCA) – a systematic review and meta-analysis

Clinical aspects of ischemia with no obstructive coronary artery disease (INOCA)

Authors: Alexander Polyak, Janet Wei, Martha Gulati, Noel Bairey Merz https://www.sciencedirect.com/science/article/pii/S2666602223001052#:~:text=Patients%20with%20INOCA%20have%20frequent,and%20social%20QOL%20%5B14%5D

Invasive coronary function testing in patients with INOCA – a single center experience

Authors: A Ferreira, R Teixeira, V Ferreira, T Mendonca, T P Silva, H Rodrigues, F Silva, F Marques, E Oliveira, R C Ferreira, R Ramos https://academic.oup.com/eurheartj/article/44/Supplement_2/ehad655.1469/7392123

The Spontaneous Coronary Slow-Flow Phenomenon: Reversal by Intracoronary Nicardipine

Authors: Hetal H. Mehta, MD;  Mackenzie Morris, MD;  David L. Fischman, MD  John J. Finley, IV, MD;  Nicholas Ruggiero, MD;  Paul Walinsky, MD;  Melissa McCarey, MPH;  Michael P. Savage, MD https://www.hmpgloballearningnetwork.com/site/jic/articles/spontaneous-coronary-slow-flow-phenomenon-reversal-intracoronary-nicardipine

Coronary microvascular dysfunction is associated with impaired cognitive function: the cerebral-coronary connection study (C3 study)

Authors: Hernan Mejia-Renteria, Alejandro Travieso, Jordi A Matías-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernández, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gómez-Garré, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-García, Jorge Matías-Guiu, Javier Escaned Keywords: Ischaemic heart disease, Coronary microvascular dysfunction, Cerebral small vessel disease, Cognitive impairment https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac521/6807333?login=false

Coronary Endothelial dysfunction predicts adverse CV events in patients with INOCA. First results of the Spanish ENDOCOR registry

Lilian Grigorian-Shamagian Juan Francisco Oteo Alejandro Gutiérrez-Barrios Omar Abdul-Jawad Altisent Ignacio Amat-Santos Agustín Fernández Cisnal JessicaRoa CarlosArellano Serrano Edgar Fadeuilhe Carlos Cortés RicardoSanz-Ruiz María Eugenia Vázquez-Alvarez Felipe Díez Delhoyo María Tamargo Javier Soriano Jaime Elízaga Francisco Fernández-Avilés Enrique Gutiérrez https://www.sciencedirect.com/science/article/pii/S0167527322016801?dgcid=author#f1070

Prognostic association of plasma NT-proBNP levels in patients with microvascular angina – A report from the international cohort study by COVADIS

Akira Suda Jun Takahashi Maike Schwidder Peter Ong Daniel Ang Colin Berry Paolo G. Camici Filippo Crea Juan-Carlos Kaski Carl Pepine Ornella Rimoldi Udo Sechtem Satoshi Yasuda John F. Beltrame C.Noel Bairey Merz Hiroaki Shimokawa on behalf of the Coronary Vasomotor Disorders International Study COVADIS Group https://www.sciencedirect.com/science/article/pii/S2352906722001889

Coronary Functional Abnormalities in Patients With Angina and Non obstructive Coronary Artery Disease

Authors: Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu, Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa.  Lay summary: Various types of coronary microvascular dysfunctions (CMD), such as epicardial coronary artery spasm, reduced coronary flow reserve, and increased coronary microcirculatory resistance, are frequently overlapped even in the … Continue reading "Coronary Functional Abnormalities in Patients With Angina and Non obstructive Coronary Artery Disease"

Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA

Authors: Kensuke Nishimiya, Akira Suda, Kento Fukui, Kiyotaka Hao, Jun Takahashi, Yasuharu Matsumoto, Kiyoto Mitsuishi, Tasuku Watanabe, Kazuma Ohyama, Jun Sugisawa, Satoshi Tsuchiya, Koichi Satoh, Tomohiko Shindo Shigeo Godo, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa.  Lay summary: OCT studies demonstrate that there are close links between coronary functional dysfunction and  coronary morphological changes.    … Continue reading "Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA"

Ischemia with No Obstructive Arteries (INOCA): A review of the prevalence, diagnosis and management

Lay Summary – An updated review of INOCA – how common it is and ways in which it can be diagnosed and treated. https://www.sciencedirect.com/science/article/pii/S0146280622003176

INOCA Patient survey published in the International Journal of Cardiology

Ischaemia with no obstructive coronary artery disease (INOCA):A patient self-report quality of life survey from INOCA Internationalhttps://www.internationaljournalofcardiology.com/article/S0167-5273(22)01396-1/fulltextLay Summary: The published results of the 2021/22 survey on the impact on Quality of Life for INOCA patients.

Phenotype-based management of coronary microvascular dysfunction

Dr Daniel Tze Yee Ang, Professor Colin Berry and Professor Juan-Carlos Kaski, Lay Summary – Looking at how appropriate testing and tailored therapy can improve the prognosis and quality of life of INOCA patients https://link.springer.com/content/pdf/10.1007/s12350-022-03000-w.pdf

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L. Bhatt, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, José A. Joglar, David A. Morrow, Robert E. O’Connor, Michael A. Ross and … Continue reading "2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines"

Safety and prognostic relevance of acetylcholine testing in patients with stable myocardial ischaemia or myocardial infarction and non-obstructive coronary arteries

Rocco Antonio Montone, MD, PhD; Riccardo Rinaldi, MD; Marco Giuseppe Del Buono, MD; Filippo Gurgoglione, MD; Giulia La Vecchia, MD; Michele Russo, MD, PhD; Andrea Caffè, MD; Francesco Burzotta, MD, PhD; Antonio Maria Leone, MD; Enrico Romagnoli, MD; Tommaso Sanna, MD; Gemma Pelargonio, MD; Carlo Trani, MD; Gaetano Antonio Lanza, MD; Giampaolo Niccoli, MD, PhD; … Continue reading "Safety and prognostic relevance of acetylcholine testing in patients with stable myocardial ischaemia or myocardial infarction and non-obstructive coronary arteries"

Invasive and non-invasive assessment of ischaemia in chronic coronary syndromes: translating pathophysiology to clinical practice

Ozan M Demir, Haseeb Rahman, Tim P van de Hoef, Javier Escaned, Jan J Piek, Sven Plein, Divaka Perera Lay Summary – Discussing how doctors can use knowledge of the INOCA and its mechanisms to inform management and treatment of the patient https://doi.org/10.1093/eurheartj/ehab548

Pathophysiology of Coronary Microvascular Dysfunction

Filippo Crea, Rocco A. Montone, Riccardo Rinaldi Lay Summary – Coronary Microvascular Dysfunction and processes associated with the condition https://doi.org/10.1253/circj.CJ-21-0848

Insights to advance our management of myocardial ischemia: From obstructive epicardial disease to functional coronary alterations

C. Noel Bairey Merz, John F. Beltrame, Colin Berry, William E. Boden, Paolo G. Camici, Filippo Crea, Judith S. Hochman, Juan Carlos Kaski, Patrick T. O’Gara, Peter Ong, Carl J. Pepine, Hiroaki Shimokawa, Udo Sechtem, Gregg W. Stone Lay Summary – Improvement in the management of myocardial ischaemia https://doi.org/10.1016/j.ahjo.2021.100060

Coronary microvascular dysfunction: Considerations for diagnosis and treatment

Benita Tjoe, MD, Lili Barsky, MD, Janet Wei, MD, Bruce Samuels, MD, Babak Azarbal, MD, C. Noel Bairey Merz, MD and Chrisandra Shufelt, MD, MS Lay Summary – Diagnosis and Treatment in Coronary Microvascular Dysfunction https://doi.org/10.3949/ccjm.88a.20140

Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group

Hiroaki Shimokawa, Akira Suda, Jun Takahashi, Colin Berry, Paolo G Camici, Filippo Crea, Javier Escaned, Tom Ford, Eric Yii, Juan Carlos Kaski, Takahiko Kiyooka, Puja K Mehta, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Satoshi Yasuda, John F Beltrame, C Noel Bairey Merz Lay Summary – An in … Continue reading "Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group"

Why the Term MINOCA Does Not Provide Conceptual Clarity for Actionable Decision-Making in Patients with Myocardial Infarction with No Obstructive Coronary Artery Disease

Francesco Pelliccia, Mario Marzilli, William E. Boden, and Paolo G. Camici Lay Summary – Making Decisions in MINOCA https://doi.org/10.3390/jcm10204630

Coronary microvascular disease: current concepts of pathophysiology, diagnosis and management

Sinha Aish, Rahman Haseeb, Perera Divaka Lay Summary – Discussing recent advances in understanding CMD, testing, managenent and what the future might hold. https://journals.lww.com/cardiovascularendocrinology/Fulltext/2021/03000/Coronary_microvascular_disease__current_concepts.4.aspx

Invasive coronary physiology in patients with angina and non obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership

https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehab653/6371296

Coronary Artery Spasm — Clinical features, pathogenesis and treatment

Hirofumi Yasue, Yuji Mizuno, Eisaku HaradaLay Summary – What it is, how it develops and what the treatments are (2019)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403432

Cardiovascular issues in women: expanding diversity in medicine

Thomas F LüscherLay Summary – Discusses gender bias in Cardiac research, testing and managementhttps://academic.oup.com/eurheartj/article/40/47/3807/5675348

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Sanjiv J Shah, Carolyn S P Lam, Sara Svedlund, Antti Saraste, Camilla Hage, Ru-San Tan, Lauren Beussink-Nelson, Ulrika Ljung Faxen, Maria Lagerstrom Fermer, Malin A Broberg, Li-Ming Gan, Lars HLay Summary – How common is Coronary Microvascular Dysfunction and is it associated with a particular type of heart failure.https://academic.oup.com/eurheartj/article/39/37/3439/5077831

Ubiquitous yet unseen: microvascular endothelial dysfunction beyond the heart

Michael T Corban, Lilach O Lerman, Amir LermanLay Summary – Discusses if Endothelial Dysfunction could be in other parts of the body.http://academic.oup.com/eurheartj/article/39/46/4098/5079860

Coronary Microvascular Dysfunction Is Associated With Myocardial Ischemia and Abnormal Coronary Perfusion During Exercise

Haseeb Rahman, Matthew Ryan, Matthew Lumley, Bhavik Modi, Hannah McConkey, Howard Ellis, Cian Scannell, Brian Clapp, Michael Marber, Andrew Webb, Amedeo Chiribiri, Divaka Perera.Lay Summary – The research identifying two types of Coronary Microvascular Dysfunctionhttps://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041595

Microvascular Angina: Diagnosis, Assessment and Treatment

Angela H.E.M Maas, Dejan Milasinovic, Colin Berry, Javier EscanedLay Summary – As stated in the title of the publicationhttp://www.emjreviews.com/interventional-cardiology/article/microvascular-angina-diagnosis-assessment-and-treatment

Systemic Microvascular Dysfunction in Microvascular and Vasospastic Angina

Thomas J Ford, Paul Rocchicciolo, Richard Good, Margaret Entegart, Hany Eteiba, Stuart Watkins, Aadil Shaukat, Mitchell Lindsay, Keith Robertson, Stuart Hood, Eric Yii, Novalia Sidik, Adam Harvey, Augusto C Montezano, Elisabeth Beattie, Laura Haddow, Keith G Oldroyd, Rhian M Touyz, Colin Berry.Lay Summary – Do INOCA conditions affect other areas of the body as well … Continue reading "Systemic Microvascular Dysfunction in Microvascular and Vasospastic Angina"

1-Year Outcomes of Angina Management Guided by Invasive Coronary Function Testing (CorMicA)

Thomas J Ford and Colin BerryLay Summary – Sharing the 1 year outcomes of the CorMicA Studyhttp://interventions.onlinejacc.org/content/13/1/33

How to Diagnose and Manage Angina Without Obstructive Coronary Artery Disease: Lessons from the British Heart Foundation CorMicA Trial

Thomas J Ford, Colin Berry.Lay Summary – What was learned about INOCA conditions from the CorMicA Studyhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545998/

Vasospastic angina: A literature review of current evidence

Fabien Picard, Neila Sayah, Vincent Spagnoi, Julien Adjedj, Olivier VarenneLay Summary – updates current understanding of Coronary Artery Spasm to 2018.https://reader.elsevier.com/reader/sd/pii/S1875213618301323?token=6A57EAB3EE940E9B3D5E99628335EB5D3528FC7A12124C2158354C21CF4508F49F1C3BA68ECFCF7D627A500541B36409

Coronary Microvascular Dysfunction in stable Ischaemic Heart Disease (NOCAD and CAD)

Udo Sechtem, David Brown, Shigeo Godo, Gaetano Antonio Lanza, Hiro Shimokawa, Novalia SidikLay Summary – How establishing a diagnosis of CMVD in other cardiac conditions can have important consequences for therapy and prognosis. https://academic.oup.com/cardiovascres/article/116/4/771/5709808

Optimal Use of Vasodilators for Diagnosis of Microvascular Angina in the Cardiac Catheterization Laboratory

Haseeb Rahman, PhD, Ozan M. Demir, MBBS, Matthew Ryan, MBChB, Hannah McConkey, MBBS, Cian Scannell, MRes, Howard Ellis, BSc, Andrew Webb, PhD, Amedeo Chiribiri, PhD, and Divaka Perera, MDLay Summary – Investigating how the use of certain drugs in testing, can help accurate diagnosis and inform treatment.https://www.ahajournals.org/doi/epub/10.1161/CIRCINTERVENTIONS.120.009019

Diagnosis of patients with angina and non-obstructive coronary disease in the catheter laboratory

Haseeb Rahman, David Corcoran, Muhammad Aetesam-ur-Rahman, Stephen P Hoole, Colin Berry, Divaka Perera.Lay Summary – Defining the specific type of CMVD in patients can improve managementhttps://heart.bmj.com/content/105/20/1536

Ischemia and No Obstructive Coronary Artery Disease (INOCA): Developing Evidence-based Therapies and Research Agenda for the Next Decade

C. Noel Bairey Merz, Carl J Pepine, Mary Norine Walsh, Jerome L FlegLay Summary – Discusses the current understanding of INOCA (2017) and the need for future trials and effective therapieshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385930

The Parallel Tales of Microvascular Angina and Heart Failure With Preserved Ejection Fraction: A Paradigm Shift

Filippo Crea, C Noel Bairey Merz, John F Beltrame, Juan-Carlos Kaski, Hisao Ogawa, Peter Ong, Udo Sechtem, Hiroaki Shimokawa, Paolo G Camici, Coronary Vasomotion Disorders International Study Group (COVADIS)Lay Summary – Shows similarities in the lack of understanding in these two conditionshttps://academic.oup.com/eurheartj/article/38/7/473/2422085

Small‐Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need, and Future Directions

Colin Berry, Novalia Sidik, Anthony Pereira, Thomas J Ford, Rhian M Touyz, Juan-Carlos Kaski and Atticus H HainsworthLay Summary – Can CAS and CMVD affect other organs, in particular the brain.https://www.ahajournals.org/doi/10.1161/JAHA.118.011104

Physiological Stratification of Patients With Angina Due to Coronary Microvascular Dysfunction

Haseeb Rahman, Ozan M. Demir, Faisal Khan, Matthew Ryan, Howard Ellis, Mark T. Mills, Amedeo Chiribiri, Andrew Webb and Divaka PereraLay Summary – 2020 research outlining two different types of Coronary Microvascular Dysfunction and the possible benefits of tailored treatments.http://www.onlinejacc.org/content/75/20/2538

Testing for Coronary Microvascular Dysfunction

C Noel Bairey MerzLay Summary – Discusses the various testing available for CMDhttps://jamanetwork.com/journals/jama/fullarticle/2755842

International standardization of diagnostic criteria for microvascular angina

Peter Ong, Paolo G. Camici, John F Beltrame, Filippo Crea, Hiroaki Shimokawa, Udo Sechtem, Juan-Carlos Kaski, C. Noel Bairey MerzLay Summary – Defines standard criteria to investigate & diagnose microvascular anginahttps://www.researchgate.net/publication/319612722_International_standardization_of_diagnostic_criteria_for_microvascular_angina

Reappraisal of Ischaemic Heart Disease

Juan-Carlos Kaski, Filippo Crea, Bernard J Gersh and Paolo G CamiciLay Summary – Updates the definition, symptoms, diagnosis & therapies available for Microvascular Angina (2018)https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031373

Ischaemia without obstructive coronary artery disease: the pathophysiology of microvascular dysfunction

Aish Sinha, Haseeb Rahman, Divaka PereraLay Summary – Discusses the causes and processes of Microvascular Dysfunction.https://pubmed.ncbi.nlm.nih.gov/32852345/

Myocardial Ischemia – from Disease to Syndrome

Mario Marzilli, Filippo Crea, Doralisa Morrone, Robert O. Bonow, David L. Brown, Paolo G. Camici, William M. Chilian, Anthony DeMaria, Giacinta Guarini, Alda Huqi, C.Noel Baire yMerz, CarlPepine, Maria Chiara Scali, William S. Weintraub, William E. BodenLay Summary – Updates knowledge and understanding of INOCAhttps://www.internationaljournalofcardiology.com/article/S0167-5273(20)32112-4/fulltext

Cardiovascular disease in women: insights from magnetic resonance imaging

Chiara Bucciarelli-Ducci, Ellen Ostenfeld, Lauren A Baldassarre, Vanessa M Ferreira, Luba Frank, Kimberly Kallianos , Subha V Raman , Monvadi B Srichai , Elisa McAlindon, Sophie Mavrogeni, Ntobeko A B Ntusi , Jeanette Schulz-Menger, Anne Marie Valente , Karen G OrdovasLay Summary – Discusses the use of MRI scanning in women’s heart disease.https://pubmed.ncbi.nlm.nih.gov/32981527/

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Jelena-Rima Ghadri, Ilan Shor Wittstein, Abhiram Prasad, Scott Sharkey, Keigo Dote, Yoshihiro John Akashi, Victoria Lucia Cammann, Filippo Crea, Leonarda Galiuto, Walter Desmet, Tetsuro Yoshida, Roberto Manfredini, Ingo Eitel, Masami Koguge, Holger M Nef, Abhishek Deshmukh, Amir Lerman, Eduardo Bossone, Rodolfo Citro, Takashi Ueyama, Domenico Corrado, Satoshi Kurisu, Frank Ruschitzka, David Winchester, Alexander R Lyon, … Continue reading "International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology"

Takotsubo Syndrome Associated With Structural Brain Alterations of the Limbic System

Thierry Hiestand, Jürgen Hänggi, Carina Klein, Marlene S. Topka, Milosz Jaguszewski, Jelena R. Ghadri, Thomas F. Lüscher, Lutz Jäncke and Christian TemplinLay Summary – Uses MRI scanning to investigate the involvement of brain regions in emotional regulation and emotional changes in Takotsubo.https://www.onlinejacc.org/content/71/7/809

The expanding spectrum of acute coronary syndromes: from STEMI to coronary dissection and Takotsubo syndrome

Professor Thomas F LüscherLay Summary – What the term Acute Coronary Syndrome should now include.https://academic.oup.com/eurheartj/article/40/15/1169/5450090

Coronary microvascular disease: current concepts of pathophysiology, diagnosis and management

Sinha, Aish; Rahman, Haseeb; Perera, DivakaLay Summary – Discusses advances in understanding, diagnosis and management of CMDhttps://journals.lww.com/cardiovascularendocrinology/Fulltext/2021/03000/Coronary_microvascular_disease__current_concepts.4.aspx

Microvascular angina: quo tendimus?

Ranil de Silva, Kevin ChengLay Summary – Discusses developments and advances in the diagnosis and treatment of Microvascular AnginaEuropean Heart Journal – https://academic.oup.com/eurheartj/adance-article/doi/10.1093/euheartj/ehab534.6364044

Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association

Jacqueline E Tamis- Holland, Hani Jneid, Harmony R Reynolds, Stefan Agewall, Emmanouil S Brilakis, Todd M Brown, Amir Lerman, Mary Cushman, Dharam J Kumbhani, Cynthia Arslanian-Engoren, Ann F Bolger, John F Beltrame and on behalf of the American Hert Association Interventional Cardiovascular Cre Committee of the Council on Clinical Cardiology; Council on Cardiovascular Care Committee … Continue reading "Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association"

Fourth Universal Definition of Myocardial Infarction

Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Bernard R Chaitman, Jeroen J Bax, David A Morrow, Harvey D White, ESC Scientific Document.Lay Summary – Discusses the different types of heart attack and the treatment options.https://academic.oup.com/eurheartj/article/40/3/237/5079081

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology

Juhani Knuuti, William Wijns, Antti Saraste, Davide Capodanno, Emanuele Barbato, Christian Funck-Brentano, Eva Prescott, Robert F Storey, Christi Deaton, Thomas Cuisset, Stefan Agewall, Kenneth Dickstein, Thor Edvardsen, Javier Escaned, Bernard J Gersh, Pavel Svitil, Martine Gilard, David Hasdai, Robert Hatala, Felix Mahfoud, Josep Masip, Caludio Muneretto,Marco Valgimigli, Stephen Achenbach, Jeroen J Bax, ESC Scientific Document … Continue reading "2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology"

An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group

Vijay Kunadian, Alaide Chieffo, Paolo G Camici, Colin Berry, Javier Escaned, Angela H E M Maas, Eva Prescott, Nicole Karam, Yolande Appelman, Chiara Fraccaro, Gill Louise Buchanan, Stephane Manzo-Silberman, Rasha Al-Lamee, Evelyn Regar, Alexandra Lansky, J Dawn Abbott, Lina Badimon, Dirk J Duncker, Roxana Mehran, Davide Capodanno, Andreas BaumbachLay Summary – 2020 Expert Consensus Document. Definition, diagnosis, treatment & prognosisEUROIntervention – https://eurointervention.pcronline.com/doi/10.4244/EIJY20M07_01

Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group

Hiroaki Shimokawa, Akira Suda, Jun Takahashi, Colin Berry, Paolo G Camici, Filippo Crea, Javier Escaned, Tom Ford, Eric Yii, Juan-Carlos Kaski, Takahiko Kiyooka, Puja K Mehta, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Satoshi Yasuda, John F Beltrame, C Noel Bairey MerzLay Summary – 2021 update on Microvascular … Continue reading "Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group"

Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome

Christian Templin, Jürgen Hånggi, Carina Klein, Marlene S Topka, Thierry Hienstand, Rena A Levinson, Stjepan Jurisic, Thomas F Lüscher, Jelena-Rima Ghadri, Lutz JånckeLay Summary – Looking at whether the nervous system might play a role in and help the understanding of Takotsubo.http://academic.oup.com/eurheartj/article/40/15/1183/5366976

Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review

Viviany R Taqueti, Marcelo F Di CarliLay Summary – Looks at the process of CMVD, updates on diagnostic testing strategies, occurence, risk factors and relationship to heart failure.www.ncbi.nlm.nih.gov/pmc/articles/PMC6296779/

Microvascular and Lymphatic Dysfunction in HFpEF and its associated comorbidities

Ilona Cuijpers, Steven J Simmonds, Marc van Bilsen, Elzbieta Czarnowska, Arantxa Gonzalez Miqueo, Stephane Heymans, Annika R Kuhn, Paul Mulder, Anna Ratajska, Elizabeth A.V. Jones & Ebba Brakenhielm.Lay Summary – Coronary Microvascular Dysfunction, the links to chronic low-grade inflammation and HfPef with possible new treatment and management therapies. https://link.springer.com/article/10.1007/s00395-020-0798-y

The Who, What, Why, When, How and Where of Vasospastic Angina

John F. Beltrame, Filippo Crea, Juan Carlos Kaski, Hisao Ogawa, Peter Ong, Udo Sechtem, Hiroaki Shimokawa, C. Noel Bairey MerzLay Summary – Detailed information on Coronary Artery Spasmhttps://www.jstage.jst.go.jp/article/circj/80/2/80_CJ-15-1202/_html

Ischaemia without obstructive coronary artery disease: the pathophysiology of microvascular dysfunction

Aish Sinha, Haseeb Rahman, Divaka PereraLay Summary – Discusses the causes and processes of Microvascular Dysfunction.https://pubmed.ncbi.nlm.nih.gov/32852345/